Department of Radiotherapy


Teaching & Research Programme

Weekly teaching programme

Lecture/Topic
Day
Clinical Lecture
Monday
Medical Physics Lecture
Tuesday
Case Presentation
Wednsday
Clinical Lecture
Thursday
Radiobiology Lecture
Friday
Joint Academic Meeting
Saturday


Teaching and Training

Research
  • Cancer cervix: 
           High Dose rate intracavitary brachytherapy 

    1.  9.5Gy x 2 fractions vs 6Gy x 4 fractions (optimisation of dose schedules)
    2.  Midline shield – standard or individualised.
    3.  Variation in applicator geometry during fractionation.

  •  Head and Neck Cancer:
  1.  Protocol based studies comparing Chemoradiation therapy with radical radiation therapy schedules
  2. HDR interstitial therapy  

  • Breast Cancer
  1. Conservative surgery + radical radiation therapy in early breast cancer.
  2. Locally advanced breast cancer  - Anterior chemotherapy for down staging and possible attempt for conservation
  3. Mamoscintigraphic scanning as tumor response assessment
  • Pancreatic & Biliary Cancer
  1.  Adjuvant chemo-radiation therapy following simple cholecystectomy in carcinoma gall bladder.
  2.  Adjuvant chemo radiation therapy following whipple’s pancreatico-duodenectomy in periampulary arcinomas.
  3.  Intraluminal brachytherapy in cholangio carcinoma and extrabiliary compressions.
  • Oesophagus Cancer

  1.  Intraluminal brachytherapy.
  2.  Dose escalation studies with external beam radiotherapy.
  3.  Concomitant chemo-irradiation schedules.
  • Brain tumours
  1.   Hyperfractionation schedules.
  2.   Concomitant boost.
  3.   Thallium spect. 

  • Treatment planning

  1.  Development of 3D planning system.
  2. 3D dose distribution models.
  3. Multi sectional planning / Dose volume histograms.
  4. Numerical scoring of rival plans. 
  • Medical Physics

  1. Calibrationof indigenous linear accelerator at cancer centre, Thakurpukur & BEL, Ghaziabad.
  2. Quality assurance studies / Interface of RFA-7 with TPS.
  3. Photon / Electron dosimetry – Irregular beam, Extended SSD.
  4. Portal imaging – verification of treatment portals in head and neck & prostate cancers.

  • Tumor Biology

  1. Plasma glutathione. in head and neck cancers
  2. p53 using immunohistochemistry in head and neck cancers
  3. p53 antibody estimation using ELISA in head and neck cancers
  4. Micronuclei assay for tumour response monitoring in carcinoma cervix.
  5. p53 and apoptosis in brain tumors
  • Special Achievements

 Technology development:
 Development of 3-dimensional radiotherapy treatment planning system

The Department has successfully designed the first 3 dimensional indigenous radiation treatment planning system under a project from the Department of Electronics, Government of India in collaboration with the Centre for Development of Advanced Computing (C-DAC), Pune  and M/s TSG Integrations, New Delhi. This treatment planning system costing around Rs. 42 lakhs is presently being marketed by M/s TSG Integrations and is comparable to similar systems available world wide.
SGPGI was mainly responsible for providing the basic requirements of this 3D-TPS, conceive the different functions and applications that would be needed to make this a state-of-art 3D-TPS and carry out patient/field trials.

Present status and expansion areas

The Department is undergoing a major expansion process. Mecaserto simulator CT, Isis advanced 3D treatment planning system and lab facilities for tumor biology studies have been recently established through Indo-French assistant protocol. The department has added Clinac 600 C, a Low Energy Linear Accelerator in 2005 funded through the Ministry of Health & Family Welfare, Government of India.

The Department had also added a Clinac 2100CD, a High Energy Linear Accelerator with MLC and mMLC for establishing the state the art of radiation therapy like Stereotactic radiotherapy (SRS/SRT), Conformal radiotherapy (3DCRT) and Intensity modulated radiation therapy (IMRT), Varis network system, Eclipse and Helios treatment planning system, Multi slice CT scanner with virtual simulation and tele-radiotherapy system through a grant received from Department of Science and Technology, New Delhi, Government of India.

Further, the Ministry of Health & Family Welfare, Government of India has recognized as Regional Cancer Centre has sanctioned a grant for augmenting a MLC and Portal Imaging in the Clinac 600C, Image guided radiation therapy (IGRT) facility in Clinac 2100CD and ancillary equipment accessories.

The high dose rate brachytherapy which is being practiced over the last 10years inthe department is also planned to add ultrasound and inaged based brachytherapy to complete range of brachytherapy facilities.

Thrust areas

  • Stereotactic, Conformal RT, IMRT, IGRT
  • Tumour biology
  • Brachytherapy 
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