Department of Maternal & Reproductive health


Obstetrics is a specialty of medicine that deals with two individuals simultaneously i.e. mother and fetus and status of one affects the other. Pregnancy is a wonderful event in the life of a woman but the outcome can be devastating for the mother and/or fetus in various situations. Most of the maternal and fetal risk factors can be diagnosed before pregnancy or during pregnancy and timely intervention can be done for an optimal outcome. This is the new horizon of Maternal and Fetal Medicine.

Department of Maternal and Reproductive Health was established under Prime Minister Swasthya Surakshya Yojna in 2009. There was an urgent need to develop this sub-specialty to look after women of reproductive age especially during pregnancy. The department was started with an aim to develop patient care, research and training in maternal fetal medicine and infertility. Identifying women at higher risk of developing pregnancy related complications is one of the major thrust of the department. Women with known medical disorders like diabetes, hypertension, heart disease, liver diseases, immunological disorder etc are looked after before planning pregnancy and during pregnancy. Patients with bad obstetric history such as  repeated pregnancy loss, previous baby with malformations, syndromes or adverse pregnancy outcome are dealt in depth with counseling and necessary investigations to have a successful outcome in future pregnancy.

Fetal medicine considers “fetus as a patient” and encompasses detailed preconceptional evaluation of at risk couple including screening and ultrasound evaluation of fetus. Fetuses at risk are being identified by various non-invasive and invasive prenatal techniques such as chorionic villous sampling, amniocentesis, cordocentesis etc. Multifetal pregnancy reduction and selective fetal reduction are being done to improve the outcome in twin, triplet or higher order pregnancy.

Fetal therapy is routinely being done for various fetal conditions such as anemia, goiter, congenital heart block, supraventricular tachycardia, polyhydramnios etc. The department has performed more than 300 intrauterine blood transfusions and the smallest fetus to received blood transfusion at 18weeks with Hb of 0.9 gm/dl. This is one of the earliest intra uterine transfusions reported in world literature. The department has done very rare fetal procedures like embolisation of large placental tumor, fetal shunt for pleural effusion and amnioinfusion. Equipped with outdoor and indoor facilities with labour room and operation theater, the department looks after the women before, during and after pregnancy.

        While we strive for a “healthy mother and healthy child”, the department wishes all expecting mothers a happy motherhood.





Mandakini Pradhan
Prof & Head
MD (OBGY),
DNB, DM (Medical Genetics)

Amrit Gupta
Addl. Prof
MS (OBGY)
Indulata
Addl. Prof
MD (OBGY)
Sangeeta Yadav
Assoc. Prof
MD (OBGY)
Neeta Singh
MS (OBGY)

Residents / Students
DM /MCh/PhD Students
1.    Bhumika Bansal
2.    Archita Shaleen
3.    Gargi Sharma
4.    Shuthi R
5.    Shruti Jain
6.    Vibha Kumari
7.    Nidhi Singh
8.    Ashmina Reki
9.    Siddhidatri Mishra                      


Honors and Awards (Last 5 years only)

Prof Mandakini Pradhan
•    “Health Icon award” by Times of India by Deputy Chief Minister, Uttar Pradesh on 26th April 2018.
•    “Women achiever award” by Amar Ujjala on April 23rd 2018.
•    “Women achiever” by ETV on the International women day 14th March 2018.
•    “Health icon award” by Marvellous records Book of India By Dr Rita Bahuguna Joshi on 20th May 2017
•    “Hum Kishise kam Nehi” by Ministry of information and Broadcasting, Govt of India and Awarded by His Excellency Governor of Uttar Pradesh, 2016
•    Felicitated by Indian Medical Association, Lucknow for exemplary work on Doctors day, 2015
•    Awarded “Arnimal prize” at the 30th Annual conference AICC RCOG-2016 for paper presentation “comparision of different site of injection of potassium chloraide for multifetal        pregnancy reduction” held at Chennai, India.
•    Late Mrs. Vidya Bhasin best paper award. Multifetal Pregnancy Reduction: An experience at a tertiary care center ISOPARB PUNE, March 2014
•    Late MrsVindyaVasini best paper award on “Management of Rh negative pregnant women: where we stand”at ISOPARB 2013.

Research Projects (Last 5 years only)
Extramural: Nil
Intramural:
Dr Amrit Gupta
1. Study the association of Insulin Growth Factors I, Insulin Growth Factor II, and IGFBP 1&3 in Intrauterine Growth Restriction of fetus
Dr Indulata
To study the vitamin D levels in infertile females and to evaluate the correlation of vitamin D deficiency with antimullerian hormone levels in infertile females compare to fertile females
Dr Sangeeta Yadav
Serum bile acid levels in Indian women with intrahepatic cholestasis of pregnancy, as compared to healthy non-pregnant and pregnant women, and their relation with perinatal outcome
Dr Neeta Singh
Role of Maternal Serum Folate Receptor alpha in Fetal Neural Tube Defects
 
Publications of Last 5 Years

Dr Mandakini Pradhan
Original Articles
  1. Kashyap N, Pradhan M, Kumar P, Singh N. Acceptance of non-invasive prenatal testing by cell free foetal DNA for foetal aneuploidy in a developing country: experience at a tertiary care centre in India. Int J Reprod Contracept Obstet Gynecol. 2016; 5(3): 705-710
  2. Kashyap N, Pradhan M, Yadav S, Singh N. Invasive prenatal diagnostic procedures: a developing countries’ perspective. Int J Reprod Contracept Obstet Gynecol. 2016; 5(1): 41-47
  3. Kashyap N, Pradhan M, Singh N, Yadav S. Early Detection of Fetal Malformation, a Long Distance Yet to Cover! Present Status and Potential of First Trimester Ultrasonography in Detection of Fetal Congenital Malformation in a Developing Country: Experience at a Tertiary Care Centre in India. J Pregnancy. 2015; 2015: 623059
  4. Pradhan M, Kashyap N, Choudhury RK, Arya V. Determination of RhD Zygosity in India: To Prevent Hemolytic Disease of Newborn. Obstet Gynecol Int J, 2015;3(4): 00090
  5. Pradhan M, Anand B, Singh N, Mehrotra M. Thyroid peroxidase antibody in hypothyroidism: It's effect on pregnancy. J Matern Fetal Neonatal Med. 2013 Apr;26(6):581-3
Case Report
  1. Mehrotra M, Mehrotra A, Nair A, Srivastava A, Sahu RN, Pradhan M, Kumar R. Dissecting intracranial aneurysm in pregnancy: A rare association. Asian J Neurosurg, 2017 Jan-Mar;12(1):127-130.
  2. Mehrotra M, Mehrotra A, Nair A, Srivastava A, Sahu RN, Pradhan M, Kumar R. Intracranial hemorrhage from giant aneurysm in pregnancy: A rare association. Asian J Neurosurg, 2017 Jan-Mar;12(1):142-144.
  3. Namrata, Mandakini Pradhan, Neeta Singh and Sangeeta Yadav. Dilemma of Fetal Autosomal Dominant Polycystic Kidney Disease, a Disease Rare to Present in Fetal Life. International Journal of Medical and Pharmaceutical Case Reports, 2015 Oct;5(5):1-7.
  4. Ranganath P, Pradhan M. Complete Pentalogy of Cantrell with craniorachischisis: a case report. J Prenat Med, 2012 Jan; 6(1):10-12.
  5. Pradhan M, Singh N, Singh AK, Kumari N. Rare association of fetal posterior urethral valve with ureteric stricture. J Prenat Med. 2012 Jan; 6(1):1-3.
  6. Verma A, Sachan D, Bajpayee A, Elhence P, Dubey A, Pradhan M. RhD blocking phenomenon implicated in an immunohaematological diagnostic dilemma in a case of RhD-haemolytic disease of the foetus. Blood Transfus. 2012 Jul 4:1-3.
  7. Pradhan M, Anand B, Singh A. Hepatitis e virus infection causing isolated fetal ascites: a case report. Fetal Diagn Ther. 2012;32(4):292-4.
Book chapter
  1. Mandakini Pradhan. Genetics for obstetrician , 2012 in FOGSI FOCUS a publication by FOGSI
  2. Mandakini Pradhan. Antenatal care, 2013, FOGSI Safe Motherhood Bulletine
  3. Mandakini Pradhan. Management of Rh negative pregnancy, 2014; FOGSI Manual for obstetrics and gynecological  Practitioners.
  4. Ratna Biswas, Mandakini Pradhan. Prenatal Diagnosis , Management of High risk pregnancy A practical approach by Jaypee Publisher, second edition; 2014: 1-26.
Dr Amrit Gupta
Original Articles
  1. Jaiswar SP, S. M. Natu, Amrit Gupta, Shweta Chaurasia. Association Between  Lactate  Levels in Vaginal Fluid and Time of Spontaneous Onset of Labor in Suspected Cases of Prelabor Rupture of Membranes: Journal of Obstetrics and Gynecology of India June 2013;63(3): 182–185.
  2. Lata Indu, Tewari S, Gupta A, Yadav S, Yadav S., To study the vitamin D levels in Infertile females and correlation of vitamin D deficiency with AMH levels in comparison with fertile females Journal of Human Reproductive Science 2017;10:86-90
Case Report
  1. Deepti Sachan, Amrit Gupta, V. Shenoy, Preeti Elhence; A near-miss hemolytic transfusion reaction and hemolytic disease of the newborn due to anti-c antibodies in a Rh (D)-positive mother: Implications for immunohematological management in pregnancy. Asian Journal of Transfusion Science, 2012; 6(1): 48-49.
  2. Vijai Datta Upadhyaya, Basant Kumar, Amrit Gupta, Kirti Naranje, Anita Singh., Jejunal Windsock Deformity: A Rare Cause of Incomplete Neonatal Intestinal Obstruction J Neonat Surg. 2016; 5:57.
Dr InduLata
Original Articles
  1. Lata Indu, Tewari S,Gupta A,Yadav S, Yadav S. To study the vitamin D levels in Infertile females and correlation of vitamin D deficiency with AMH levels in comparison with fertile females Journal of Human Reproductive Science 2017;10:86-90
Case Report
  1. Lata I. Spontaneous successful pregnancy in posthypophysectomy hypopituitarism: A rare case report .Journal of Human Reproductive Science 2014;7(3):218-220
  2. Lata I, Kapoor D, Zafar N. Ruptured rudimentary horn pregnancy misdiagnosed as ruptured pseudo aneurysm internal iliac artery, Letter To Editor in International Journal of Critical Illness and Injury Science 2013;3(4):384-85
  3. Lata I, Mohindra Samir. A case report “Pancreatic Pseudocyst in Pregnancy and outcome: a rare case report and Review of literature”.Indian journal of Obstetrics and Gynaecology 2016 Sep-Dec;4(3).279-282.
  4. Lata I, Kapoor Deepa. “A rare case of functional ectopic hyperthyroidism- Struma Ovarii”. World Journal of Endocrine Surgery, 2016;8(3):212-213
  5. LataIndu, Mohindra Sameer. Pancreatic pseudocyst in pregnancy and outcome a rare case report and review of literature. Indian Journal of Obstetrics and Gynaecology 2016;4(3):279-82.
  6. LataIndu, Kapoor Deepa, Kumar Sudeep, Sahu Sandeep. Complicated pregnancy in polycystic ovarian syndrome after moderate ovarian hyperstimulation syndrome (OHSSS) followed by peripartum cardiomyopathy. Indian Journal of maternal fetal and neonatal medicine 2017;4(1):73-76.

Book Chapter
  1. InduLata, Sahu S, Agarwal S. Trauma in Pregnancy in textbook of Obstetric Anaesthesia by Dr Amit Padvi et al published by CBS Publishers & Distributors Pvt. Ltd. First Edition 2016, Chapter no.17,Pages;235-251 .ISSN : 9789385915239
  2. SahuS ,Shamshery C, LataIndu. Obstetric Anesthesia for non-obstetric Procedures in textbook of Obstetric Anaesthesia by Dr Amit Padvi et al published by CBS Publishers & Distributors Pvt. Ltd. First Edition 2016, Chapter no.18, Pages;252-270 .ISSN : 9789385915239
Review Article
  1. Lata I. Hepatobiliary diseases during pregnancy and their management, an update, Review Article. International Journal of Critical Illness and Injury Science 2013;3(3):175-182.
  2. LataIndu. Zika Virus and pregnancy, what is must to know for an obstetrician. Indian Journal of Obstetrics and Gynaecology 2017;5(3):111-19.
Dr Sangeeta Yadav
Original Articles
  1. Kashyap N, Pradhan M, Singh N, Yadav S. Early Detection of Fetal Malformation, a Long Distance Yet to Cover! Present Status and Potential of First Trimester Ultrasonography in Detection of Fetal Congenital Malformation in a Developing Country: Experience at a Tertiary Care Centre in India.. J Pregnancy. 2015: 623059. (Published online 2015 Nov 23)
  2. Kashyap N, Pradhan M, Yadav S, Singh N. Invasive prenatal diagnostic procedures: a developing countries’ perspective. Int J ReprodContracept Obstet Gynecol. 2016;5(1):41-47
Case Report
  1. Namrata, Mandakini Pradhan, Neeta Singh and Sangeeta Yadav. Dilemma of Fetal Autosomal Dominant Polycystic Kidney Disease, a Disease Rare to Present in Fetal Life! International Journal of Medical and Pharmaceutical Case Reports. 2015 Oct;5(5):1-7.
Dr Neeta Singh
Original Articles
  1. Kashyap N, Pradhan M, Singh N, Yadav S. Early Detection of Fetal Malformation, a Long Distance Yet to Cover! Present Status and Potential of First Trimester Ultrasonography in Detection of Fetal Congenital Malformation in a Developing Country:Experience at a Tertiary Care Centre in India.. J Pregnancy. 2015: 623059. (Published online 2015 Nov 23)
  2. Kashyap N, Pradhan M, Yadav S, Singh N. Invasive prenatal diagnostic procedures: a developing countries’ perspective. Int J ReprodContracept Obstet Gynecol. 2016;5(1):41-47
  3. Kashyap N, Pradhan M, Kumar P, Singh N. Acceptance of non-invasive prenatal testing by cell free foetal DNA for foetal aneuploidy in a developing country: experience at a tertiary care centre in India. Int J Reprod Contracept Obstet Gynecol. 2016;5(3):705-710
  4. Pradhan M, Anand B, Singh N, Mehrotra M. Thyroid peroxidase antibody in hypothyroidism: It's effect on pregnancy. J Matern Fetal Neonatal Med. 2013 Apr;26(6):581-3
Case reports
  1. Namrata, Mandakini Pradhan, Neeta Singh and Sangeeta Yadav. Dilemma of Fetal Autosomal Dominant Polycystic Kidney Disease, a Disease Rare to Present in Fetal Life! International Journal of Medical and Pharmaceutical Case Reports. 2015 Oct;5(5):1-7.
  2. Pradhan M, Singh N, Singh AK, Kumari N. Rare association of fetal posterior urethral valve with ureteric stricture. J Prenat Med. 2012 Jan;6(1):1-3
Book Chapter:
  1. First Trimester Screening for Fetal Aneuploidy. In: Screening in Obstetrics & Gynecology: Management of Abnormality. A FOGSI Publication. Jaypee 2014; Pp 25-34
  2. Fetal Therapy. In - Innovations in Practical Obstetrics – Are they useful, what does evidence say. A FOGSI Publication .2015
Workshop / Conferences / Symposium Organized
Symposium on “ At risk mother and fetus” at SGPGIMS on January 2014.

Outstanding Features & Summary
The department has established it’s mark as a referral center for Maternal and Fetal Medicine.  It is one of the centers in India to train doctors of Obstetrics and Gynecology in management of high risk pregnancy and prenatal diagnosis of fetal diseases like Down syndrome, beta thalassemia, various fetal malformations etc . The department also imparts experience in invasive and non-invasive treatment of fetal conditions like fetal heart disease, fetal transfusion etc. One year post doctoral certificate course is offered in “Maternal and Fetal Medicine” to Obstetrician and Gynecologist which trains them to do fetal ultrasound, it’s implication and future course of action. It’s the department to do rare fetal interventions like treatment of fetal goiter by intra-amniotic instillation of Levothyroxin tablet and embolisation for placental tumor with successful fetal outcome which was done for the first time in India. Pregnant women with cancers, tumors, heart diseases, liver diseases and recurrent abortions are looked after with an aim to have successful pregnancy outcome.

Future Plans

1. Prediction and prevention of complications of pregnancy related diseases like pregnancy induced hypertension, preterm delivery, stillbirth and birth of a malformed baby etc. to decrease maternal mortality ratio and perinatal mortality rate.
2. Expanding the horizon of fetal therapy.



 
 

 



 



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